DR. ALLISON PAOLINI, PH.D., NCC
A FREE CLINICAL DIAGNOSTIC TOOL · STEP 1 OF 5

The 10-Flag Clinical Screen for Immune-Mediated Implantation Failure

If your labs are "normal" but your cycles keep failing — this is the diagnostic tool most women never get.

From Dr. Allison Paolini, Ph.D., NCC — counselor educator, fertility advocate, immune-infertility survivor. I lost two pregnancies before a reproductive immunologist found what my RE missed.

If you're "doing everything right" — good embryos, normal labs, clean ultrasounds — and your cycles are still failing, the problem is not the embryo. It is the environment.

Standard OBGYN care stops at the surface. Reproductive Immunology goes deeper — to the uterine lining, the immune cells patrolling it, and the inflammatory signals silently shutting implantation down. The gap between these two fields is where most unexplained infertility actually lives.

10 yes/no questions. Answer honestly — even for symptoms you've been told are unrelated to fertility. Your immune system is one system. What shows up in your joints, skin, gut, and sinuses is the same inflammatory engine deciding whether an embryo gets to implant — or gets rejected as foreign tissue.

10 questions
~3 minutes
Clinical risk score
Flag 1 of 10
FLAG 01
CHRONIC INFLAMMATION
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YOUR URGENCY SCORECARD

Zone Name

You answered X of 10 yes

The Three Tests Your Standard Workup Missed

Endometrial Biopsy (CD138) Detects chronic endometritis — silent uterine infection that prevents implantation. Present in 28–66% of women with recurrent implantation failure.
Natural Killer (NK) Cell Panel Measures uterine rejection risk. The critical measurement is cytotoxicity, not the count. Requires specialized immunology labs.
Th1 / Th2 Cytokine Ratio Measures inflammatory immune balance. Th1-dominant patterns are strongly associated with recurrent loss.
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PH.D. INSIGHT
You are not unexplained. You are under-investigated. The CD138 biopsy is typically ordered by your RE. The full systemic immune workup — NK cytotoxicity, Th1/Th2, thrombophilia panels — requires a Reproductive Immunologist.
"Unexplained" is not a diagnosis.
It is a gap in testing.